The Brain Glymphatic System – A Beginner’s Guide

Neurochem Res. 2015 Dec; 40(12): 2583–2599.

Key Takeaways: The Glymphatic System—Why Sleep Matters More Than You Think

The glymphatic system is the brain’s waste clearance network, using fluid channels surrounding blood vessels to remove toxins, including proteins linked to neuroinflammation.

This system is mainly active during sleep—especially deep, slow-wave sleep—and is largely shut down during wakefulness.

It not only clears waste but helps distribute essential compounds like glucose, amino acids, and neuromodulators across the brain.

Impaired glymphatic function is associated with neurodegenerative diseases, traumatic brain injury, and stroke, suggesting its central role in brain health and repair.

These findings support the idea that sleep is not just restorative—it’s essential for detoxifying the brain and maintaining neurological balance.

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IMPORTANT

The information provided in this article is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. It is crucial to consult with medical doctors or qualified functional medicine practitioners to address specific health concerns and obtain personalised guidance tailored to individual needs. Never add any supplements to your plan until it has been assessed and approved by your medical doctor or a suitable qualified practitioner who is familiar with your health history.

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