OCD and Low IgA levels – Our First Line of Defence Against Microbes

Immunoglobulin A (IgA) levels can be measured easily in blood and in this retrospective cohort study, a significant number of children with OCD  had consistently low IgA levels, comparable only to those diagnosed with coeliac disease. IgA is the first line of defence against harmful microbes, and crucial for maintaining immune tolerance. Low levels increase the risk of allergies and autoimmune disease. IgA is found primarily in the following areas

  • Gut mucus (intestinal barrier)
  • Saliva
  • Tears
  • Breastmilk
  • Respiratory mucus
  • Urogenital mucus

Essentially low IgA level means that immunity is weakened which increases the risk of infections, as well as gut disorders and autoimmunity. Here are are some of the most evidence-based interventions for increasing IgA levels:  Using probiotics, especially L. reuteri, L. casei and B. bifidum,  prebiotics, especially those containing fructooligosaccharides, L- Glutamine, crucial for gut health, chlorella, vitamin A, ginseng and Resihi mushrooms. Relaxation, music, humour, moderate exercise have also been shown to increase IgA levels.  Read more…

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