Gut Protective Nature of Lactobacillus Plantarum in NSAID Use

https://doi.org/10.3389/fimmu.2017.01000

We work with a lot of children who take NSAIDs (non-steroidal anti-inflammatory drug) prescribed by their medical team. In many cases, these children tend to be those who suffer from PANS or PANDAS, where, in clinical practice, the link to gut health is of major significance. The children don’t need to be suffering from major overt GI issues like constipation or diarrhoea which is expected, but they can have all the hallmarks of poor nutrient absorption or disturbed microbiome, including small intestinal bacterial overgrowth (SIBO) or poor release of stomach HCL with all the knock-on effects which it can have in maldigestion. In this randomized placebo-controlled cross-over trial, healthy human subjects were given Lactobacillus plantarum supplementation to see the impact on mucosal health while being treated with NSAIDS. The results were encouraging in terms of positive impact on host immunity. Read more…

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